DMSO Dimethyl Sulfoxide Uses in Canine Feline Veterinary Patients

DMSO Dimethyl Sulfoxide Uses in Canine Feline Veterinary Patients

DMSO has strong antioxidant capabilities. DMSO finds certain “aspects” of cancer cells chemotactically attractive and binds to cancer cells preferentially over regular cells. Scientists can use this to carry certain drugs to strategic positions relative to those cancer cells.

DMSO is useful in snake bite and other medical conditions. This is the purpose of THIS ARTICLE ON DMSO in Cats and Dogs.

For this article I’m going to describe DMSO Dimethyl Sulfoxide Uses in Canine Feline Veterinary Patients

We needed to get DMSO into patients based on some case studies we read about as far back as 1981. Mainly we used it for SNAKE BITES, it neutralizes the damage caused by the snake venom in Copperhead bites. So you smear it on hard. ASAP after the bite. And you can give it IV (intravenously) alongside some fluids. We USED to give injections straight-up through an IV catheter. But the DMSO (undiluted) would cause inflammation / caustic vasculitis RIGHT there at the catheter contact with the inside of the vein. And if you got DMSO outside the vein, OUCH.

SO we used catheters and ran it alongside copious fluids.

Then one day, I wondered if it was possible to give DMSO under the skin. Like, diluted. So I diluted it 50:50 and tried it on myself.

It might as well have been a WASP STING. omfg so painful. And like, for the first 3-5 seconds, I was like “Oh that’s not bad” and then came the surging hounds of hell baying and biting. Over an hour. Ouch.

I diluted it again and again until I got it down to 12 cc in 1 liter of 0.9% NaCl. THAT mixture can be run under the skin with nominal discomfort. It’s still a little uncomfortable. Even a little bit later. But by the next day you can’t tell it was done unless some fluids remain at the site.

12 cc in 1 liter of 0.9% NaCl.

And you run the fluids exactly the way you’d run “regular” fluids. So if I’d give a cat 100cc of regular LRS or NaCL I can run the same volume in the DMSO/NaCl fluids.

Did you know that dimethyl sulfoxide can remain in the system for up to 8 days? This bodes well for the compound for arthritis. It was found to be better in cats than dogs as far as CNS pain. I have not gone hard into that niche with it.

Mostly I like DMSO Fluids for:

  • Elderly dogs and cats with certain organ-impairments from kidney to (especially) liver.
  • Icterus (Paired with ursodehydrocholic acid)
  • Snake bite
  • Arthritis

You can use a “roll on” version of straight-up 99% undiluted DMSO on envenomations and any other “cellulitis” or tissue edema where Lysozomal membranes need to be stabilized, and can use it alongside steroids like Prednisone/Prednisolone.

Also, randomly, I really, REALLY love this song:


Author: Dr. Erik Johnson
Dr. Erik Johnson is the author of several texts on companion animal and fish health. Johnson Veterinary Services has been operating in Marietta, GA since 1996. Dr Johnson graduated from the University of Georgia College of Veterinary Medicine in 1991. Dr Johnson has lived in Marietta Georgia since 1976.