SupaVerm Closantel Mebendazole Against FlukesDr Erik Johnson 2019-11-07 0 COMMENTS
Supaverm was used for Flukes when Praziquantel was too expensive. Supaverm would still have a use in eradication of GOLDFISH from Koi ponds because it is selectively toxic to goldfish, not Koi. What follows is a legacy article from when I doped out how to use Supaverm more than a decade ago. It’s still relevant in that someone might still HAVE to use Supaverm, someone might be killing off goldfish, or someone might be curious about Closantel or Mebendazole in fish.
SupaVerm Closantel Mebendazole Against Flukes
Erik L. Johnson, D.V.M. Fish Health Specialist, Veterinarian
A Closantel/Mebendazole combination (Supaverm) was tested in eight discrete systems on several species of fish, with Goldfish and Koi in the majority. Within five to seven days from the first applications of Closantel/Mebendazole combination, and replicated in eight different systems, every member of every species of goldfish was 100% annihilated including Ranchus, Pembrookes, Midnights, Wakins, Telescopes, Shubunkins and Comets. Salt appears to enhance the killing effect of Closantel/Mebendazole combination on flukes. Carbon does not remove sufficient compound to save the Goldfish in treated systems. There appears to be no negative effect of Closantel/Mebendazole combination on Koi. Closantel/Mebendazole combination was 100% effective in the eradication of flukes in all systems in less than 36 hours without negative effect on plants, Koi or filter.
Body of Article:
Research is finishing up on Closantel/Mebendazole combination, branded “Supaverm” from the UK. We’re going to watch all surviving treated fish for signs of toxicity for several more weeks. We are not tracking changes in blood parameters. This would be interesting if funding was available.
“Supaverm” is the trade name of a nematode and cestode treatment from Janssen Animal Health. The active ingredients are Closantel (5mg/ml) and Mebendazole (75mg/ml).
Mebendazole belongs to the chemical group of benzimidazolecarbamates. Its full chemical name is: Methyl 5-benzyl-1H-benzimidazole-2yl-carbamate.
This is a new broad-spectrum anti-parasitic medicine. It is especially effective against nematodes and cestodes, including hepatic flukes. Closantel’s full chemical name is: N-[5- chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid. Molecular formula of Closantel is C22H14Cl2I2N2O2
Mr. Chuck Downs had read with interest the reports from the UK concerning this compound and made arrangements to provide us with some Closantel/Mebendazole combination for testing purposes.
He writes: “Recently, I’ve discovered that koi keepers throughout the UK and even some of the breeders in Japan have been using a new treatment for flukes called Supaverm. From what I know, Supaverm is actually a ‘sheep dip’, and contains Closantel at 5 mg/l and Mebendazole at 75 mg/l as the active ingredients. The results look fantastic, with universal 100% elimination of flukes, with only one treatment (adults, eggs, etc. all wiped out)”.
“The nice part is the dosage is extremely low (2.2 ml per ton, or 1000 liters). Since my pond is 22,000 gallons (roughly 85,000 liters), that only amounts to 187 ml to treat my pond. A gallon of the stuff costs around $50 US, but I think you can only get it in the UK.”
Eight systems were treated with Closantel/Mebendazole combination.
(1) Red tail catfish 22″
(8) Koi varying from 5″ to single specimen of 18 inches.
(12) Pembrooke Goldfish
(7) Wakin goldfish
Pacu, Alligator snapping turtles.
(4) Shubunkin Goldfish
(4) Shubunkin Goldfish
(4) Shubunkin Goldfish
4000 Gallon pond
Koi and Koi:Comet hybrids
300 gallon pond
(12) Ranchu Goldfish breeder adults
(2) Small Koi
Systems one through three were also treated with 0.3% salt.
Systems four through six used carbon in their filtration.
Each system was populated with fish. In all of the systems containing Koi or Goldfish, the presence of flukes was confirmed by microscopic biopsy of skin, gills and fins. The systems with the other fish were included to test the safety of this compound with unknown (heretofore untested) species of fish.
The U.K. dose of this compound is 1 ml per 90 British gallons. We dosed 1 ml per 100 US Gallons.
On Day one, each system was treated with the equivalent of (1) one-milliliter of Closantel/ Mebendazole combination suspension per 100 US Gallon of water.
In systems one through three, no second treatment was needed for the flukes. Microscopic biopsy confirmed that the flukes were entirely gone within only 12 hours. Ich remained on these fish for three more days and disappeared.
In systems four through six, a second biopsy at the twelve-hour mark showed abundant flukes. These systems were not salted, and they contained carbon. It is possible that the carbon removed some of the Closantel/Mebendazole combination, or more likely; that the salt accentuates the Closantel/Mebendazole combination effect on the flukes.
In systems four through six we re-applied the Closantel/Mebendazole combination at double strength, twenty-four hours after the first application. After twelve more hours, flukes were completely gone from treated fish.
Well, that’s where the story normally would end, and I sent out a message hearkening the “beginning of the end” for Flukes. To the day, seven days after the first treatment in systems one through three, the goldfish began to die in threes and fours with almost no symptom except lethargy, slowed respiration and reaction-time, plus excess slime coat.
System four through six were set up all at the same time in parallel, and those fish died within five days of application. (Higher dose used results in speedier kill?)
System Seven and eight saw the end of all resident goldfish two days later. (I had waited to treat these systems with Closantel/Mebendazole combination for 48 hours to see if the drug would be toxic.)
System Seven contained Goldfish-Koi hybrids, and these hybrids are still alive eleven days after the first treatment.
No Koi was adversely affected by the Closantel/Mebendazole combination.
100% of Goldfish treated are dead. They died in each system over 36 hours from start to finish with 100% morbidity and 100% mortality.
“I lost a lot of beautiful Goldfish by not waiting more than seventy two hours to call it “safe”. I mean, I lost like sixty extremely large Goldfish. I am very glad I lost the fish and did not send out information that would have killed yours. ” Doc Johnson
SupaVerm Two Addenda to Closantel Mebendazole Testing
SupaVerm II – by Doc Johnson
See also SupaVerm III
Supplement to Closantel work:
“Any idea about how long this stuff lasts in the system? ” – NO
“Also, any idea whether the Closantel or Mebendazole killed the goldfish? ” – Actually, we don’t even now for sure whether it was the Closantel or the Mebendazole part which killed the flukes, let alone the goldfish.
From Peter Waddington:
Re- Supaverm, we have used this for some 3-4 years & would report as follows:
It is a suspension rather than a liquid and MUST be shaken thoroughly every time before measuring out for dosages to ensure the correct amount of active ingredient is within the overall dose.
It is also light-degradeable so ensure opaque bottles are used also store in a dark place.
I have no experience in using Supaverm – or any other Koi medications we use, on any other species of fish life. However I do know a colleague of mine who has a water garden centre nearby used Supaverm on thousands of Israeli goldfish from 1″ to large sizes with no ill-effect – all flukes destroyed, however he did not use salt at same time. At the same time I have heard that others have killed goldfish by just using Supaverm on its own.
Although my company and many Japanese breeders have used this product with amazing success and continue to do so if flukes manifest themselves with complete confidence. There have been others who have suffered problems which do not add up at all.
One fellow, two years ago, inadvertently dosed his pond with a double dose of Supaverm – Koi looked a little miserable but next day were all fine – no further related problems or damages due directly to this mistake.
Several UK dealers have used Supaverm on day one & then have used it again on, say day seven – as they would with, say potassium. They have had no microscope so assume eggs may have hatched since day one. On several occasions the first dosage has proved totally safe to the Koi but the follow-up has produced problems at day 2 AFTER the second dosage.
White skin changes to red skin & Koi look very sick. Most eventually recover but I do not know the exact reason for this.
In any case we do not use automatic follow-up dose on any medication unless microscope reveals a problem.
Note From Doc Johnson
“The active ingredients in Fluke Tabs are Trichlorfon and Mebendazole.” Doc Johnson
“The presence of Mebendazole in the Fluke Tabs is probably the reason for the occasional pinking you see in Goldfish if the Fluke Tabs are not removed expediently.” Doc Johnson
SupaVerm III Third Addenda to Supaverm Information
SupaVerm III – by Doc Johnson
You can sometimes get SupaVerm for less from your local livestock ranchers. Do NOT tell them that you’re using it for fish.
Recently, discussion about SupaVerm dosing.
A company with which I consult has recommendations for three doses. Their product is not watered down. They are doing what I suggest they do as far as dosing. Here’s how that was derived.
This is because when I first tested SupaVerm, I found some systems had flukes after treatment #1. Hopefully ya’ll have read the results carefully??
“In systems one through three, no second treatment was needed for the flukes. Microscopic biopsy confirmed that the flukes were entirely gone within only 12 hours. Ich remained on these fish for three more days and disappeared.
In systems four through six, a second biopsy at the twelve-hour mark showed abundant flukes. These systems were not salted, and they contained carbon. It is possible that the carbon removed some of the Closantel/Mebendazole combination, or more likely; that the salt accentuates the Closantel/Mebendazole combination effect on the flukes.”
The Brits use one dose. That’s fine, but do they also do microscopic studies in *all* instances to confirm efficacy? Maybe not. But I did. And in some cases two doses were required.
The next thing was “use in the field”.
Just a minute…You should be aware that quite a few of the ‘pundits’ you may listen to don’t even have Koi of their own. Some of them never have owned Koi. Some of them have never even used SupaVerm and still write all about it. You have to know this happens all the time. Like when Alabama’s J. B. had all that “hot new warning information” about Program(tm), which has safely come into widespread use among fish despite her initial dire predictions..
I have Koi, I have had almost a dozen different ponds over the last few years, and I use SupaVerm extensively in my own collection whenever I get a new fish in; because my mortal fear is the darn Flukes!
So I know what I am talking about. I ALWAYS use two treatments, usually a day or two apart. I personally don’t, and have not had to use, three doses.
Then there’s the “use in the field” thing.
When “clinical experience” converts into field trials, there’s less control over the “variables” so not everything I found to be true is gospel, but I consult with Blue Ridge Fish Hatchery, Carl Forss, and Ed Otero on occasion as they try to help their customers and-or friends, and it has started to “trickle in” that (because they are all competent to use a scope) they sometimes find flukes after about ten days, even with the two treatment regimen.
Universally, that delayed “third treatment” nips these off and the problems are solved.
So, use one dose if you want…There are those using SupaVerm once, who believe something is true just because they say it is so. “Flukes are gone” – okay, whatever you say, governor.
Or, use three doses.
But in the personal expenditure of a whole liter over the last year on my fish and in the cases and facilities I’ve prescribed it; I’ve encountered no neurologial problems. That’s plain old hysteria. A kind of ‘propaganda’ with the flavor of “Listen to me, I have some secret conspiratorial information no one else knows.”
I am sure Pete Waddington and the folks who have used SupaVerm for years are laughing at the neurological signs ‘voodoo’ we are ascribing to the product.
Experience. It’s really needed, before hysterical comments are made.
This is the nut shell: Use SupaVerm for flukes once. Wait one day. Biopsy with your microscope. Only treat again if there are flukes left. If you have to treat again, Treat on day “three”. Biopsy again twenty four hours later. If no flukes are found, probably you’re clear. Biopsy again on day ten to make sure you’re right. If no flukes are found, you’re done.
Here’s the dosing regimen in case you don’t have a scope or don’t want to mess with it:
DOSE: One milliliter per one hundred US Gallons, on “Day One”, “Day Three” and “Day Ten” without water changes or bypassing the filter. Remove carbon from the filter.
The ONLY symptom I ever saw with fish having a reaction to SupaVerm was in several species *other* than Koi. I have never seen any reaction in Koi. Ever.
And in the affected species, all I ever saw was skin reactions – just an incredible, runny slime coat, and pinking up, and then death in most instances among the following species – Goldfish, Hi-Fin
Banded sharks, Plecostomus (50%) and it really mauled but did not kill the redtail catfish.
Anyway, this is offered as some clarification of the dose on SupaVerm and how it has evolved.
“SupaVerm is pretty dang safe.” Doc Johnson
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Dr Erik Johnson is a Marietta, Georgia Veterinarian with a practice in small animal medicine. He graduated from University of Georgia with his Doctorate in 1991. Dr Johnson is the author of several texts on Koi and Pond Fish Health and Disease as well as numerous articles on dog and cat health topics.