Mult-Drug-Resistance-1 (MDR-1) Gene in Dogs What Does It Mean?

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We sent some samples out for genetic DNA testing on a dog, to find out what breeds he was and one of the tests came back positive for the MDR-1 gene. The owner asked me what that was, and whether it mattered or not.

Mult-Drug-Resistance-1 MDR-1 Gene in Dogs What Does It Mean?

In a nutshell it means that the dog MAY have trouble excreting a drug we might give. That means that things like sedative, loperamide, epilepsy medicine, and other medicines that are heavily processed by the liver for excretion may remain in the system longer than in other dogs.

Sedatives hit harder. Heart medicines stay around longer (and may work better) etc.

Mult-Drug-Resistance-1 (MDR-1) Gene in Dogs What Does It Mean?

Mult-Drug-Resistance-1 (MDR-1) Gene in Dogs What Does It Mean?

I downloaded information on MDR-1 because it explains it, some and also lists some of the drugs that can remain ‘too long’ in these MDR-1 dogs.

Mult-Drug-Resistance-1 MDR-1 Gene in Dogs What Does It Mean?

Mdr1 Collie

MDR1_multi_drug_resistance_one_sheet

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Dr Erik Johnson

Dr Erik Johnson is a Marietta, Georgia Veterinarian with a practice in small animal medicine. He graduated from University of Georgia with his Doctorate in 1991. Dr Johnson is the author of several texts on Koi and Pond Fish Health and Disease as well as numerous articles on dog and cat health topics.