We sent some samples out for genetic DNA testing on a dog, to find out what breeds he was and one of the tests came back positive for the MDR-1 gene. The owner asked me what that was, and whether it mattered or not.
Mult-Drug-Resistance-1 MDR-1 Gene in Dogs What Does It Mean?
In a nutshell it means that the dog MAY have trouble excreting a drug we might give. That means that things like sedative, loperamide, epilepsy medicine, and other medicines that are heavily processed by the liver for excretion may remain in the system longer than in other dogs.
Sedatives hit harder. Heart medicines stay around longer (and may work better) etc.
I downloaded information on MDR-1 because it explains it, some and also lists some of the drugs that can remain ‘too long’ in these MDR-1 dogs.
Mult-Drug-Resistance-1 MDR-1 Gene in Dogs What Does It Mean?
MDR1_multi_drug_resistance_one_sheet
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