DHEA, Colchicine, NAC and Ivermectin for Large Dog Neoplasia

A 60 pound Golden Retriever presented for a rapidly expanding “mass” (12-15mm) under the skin on the nasal planum, distorting the nose proper and the skin caudal to the nose. The lesion was slightly tender and was believed to be a bee sting. Antibiotics were used in case it was an infected or penetrating wound.

Two weeks later the lesion had doubled in size, was still hard, slightly tender and 35mm in diameter. The dog was advanced in age. (!2+ yrs) castrated male. The decision was made to take a core biopsy (3-4mm) from the lesion and see grossly what was inside the lump at collection time. In the meantime the dog was put on the following anti-tumor supplements. The total cost of these supplements is very low. Colchicine is the most expensive piece, and costs about $30 for a month supply.

For Cody

  • NAC n-acetyl-cysteine starts off at one capsule a day and increases to three capsules a day over 3 days. Then give 3 capsules a day
  • Ivermectin is 1.0 ml (one cc) by mouth every other day
  • DHEA is 6 capsules of the 100mg DHEA  –  give 6 capsules once a day or 3 capsules twice a day.
  • Geranyl Geraniol 150mg capsules –  give one capsule every day.
  • Colchicine is given at a rate of 0.6 mg (1 tablet) by mouth once a day.

Probably this will make no difference. No harm is done, and you’ve wasted $60-70 on a ‘chance’.

Maybe it will slow or stop the growth.

It’s unlikely but IS POSSIBLE that it will make a tumor regress.

 

What’s missing? Fenbendazole.

 

ivermectin-against-cancer

Dual-target inhibitors of colchicine binding site for cancer treatment – ScienceDirect

Beneficial effects and side effects of DHEA- true anti-aging and age-promoting effects, as well as anti-cancer effects of DHEA – PubMed

Dehydroepiandrosterone inhibits events related with the metastatic process in breast tumor cell lines – PMC

N-Acetylcysteine

Antioxidant Intake and Antitumor Therapy- Toward Nutritional Recommendations for Optimal Results – PMC

Dr Erik Johnson is a Marietta, Georgia Veterinarian with a practice in small animal medicine. He graduated from University of Georgia with his Doctorate in 1991. Dr Johnson is the author of several texts on Koi and Pond Fish Health and Disease as well as numerous articles on dog and cat health topics.