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Efficacy of a ghrelin-agonist in dogs 5

Fig. 5. Mean ( SD) GH serum levels on Day 1, Day 4 and Day 7 of
Fig. 6. Mean ( SD) IGF-1 serum levels on Day 1, Day 4 and Day 7 of
treatment with capromorelin or placebo.
treatment with capromorelin or placebo.
DISCUSSION
hunger centers of the hypothalamus to stimulate appetite and
thereby enhancing the food consumption (Cowley et al., 2003).
Capromorelin is a potent, selective GHS-R agonist that is orally
In this study, orally administered capromorelin in dogs was
bioavailable. Capromorelin activates GHS-R expressed on the
quickly absorbed from the gastrointestinal tract with peak
© 2016 The Authors. Journal of Veterinary Pharmacology and Therapeutics Published by John Wiley & Sons Ltd