Page 3 - Introduction to FMT
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FMT Introduction
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Fecal microbiota transplantation broadening its application beyondecal microbiota transplantation broadening its application beyond
i intestinal disorders Meng-Que Xu, Hai-Long Cao, Wei-Qiang Wang,ntestinal disorders Meng-Que Xu, Hai-Long Cao, Wei-Qiang Wang,
Shan Wang, Xiao-Cang Cao, Fang Yan, and Bang-Mao Wanghan Wang, Xiao-Cang Cao, Fang Yan, and Bang-Mao Wang
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Meng-Que Xu, Hai-Long Cao, Wei-Qiang Wang, Shan Wang, Xiao-Cang Cao, Fang Yan, Bang-Mao Wang,
Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin
300052, China Fang Yan, Division of Gastroenterology, Hepatology and Nutrition, Department of
Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-0696, United States Author
contributions: Xu MQ, Cao HL, Wang S, Cao XC and Wang BM designed the review; Xu MQ and Cao HL
analyzed the data; Xu MQ, Cao HL, Wang S and Cao XC wrote the paper; Xu MQ, Cao HL, Yan F and
Wang WQ revised the manuscript.
Correspondence to: Hai-Long Cao, MD, Department of Gastroenterology and Hepatology, General
Hospital, Tianjin Medical University, 154 Anshan Rd, Heping District, Tianjin 300052, China.
cao_hailong@163.com
Telephone: +86-22-60362608 Fax: +86-22-27813550
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Abstract
Intestinal dysbiosis is now known to be a complication in a myriad of diseases. Fecal microbiota
transplantation (FMT), as a microbiota-target therapy, is arguably very effective for curing Clostridium
difficile infection and has good outcomes in other intestinal diseases. New insights have raised an interest
in FMT for the management of extra-intestinal disorders associated with gut microbiota.
This review shows that it is an exciting time in the burgeoning science of FMT application inhis review shows that it is an exciting time in the burgeoning science of FMT application in
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previously unexpected areas, including metabolic diseases, neuropsychiatric disorders,reviously unexpected areas, including metabolic diseases, neuropsychiatric disorders,
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autoimmune diseases, allergic disorders, and tumors.utoimmune diseases, allergic disorders, and tumors.
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A randomized controlled trial was conducted on FMT in metabolic syndrome by infusing microbiota from
lean donors or from self-collected feces, with the resultant findings showing that the lean donor feces
group displayed increased insulin sensitivity, along with increased levels of butyrate-producing intestinal
microbiota.
Case reports of FMT have also shown favorable outcomes in Parkinson’s disease, multiplease reports of FMT have also shown favorable outcomes in Parkinson’s disease, multiple
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s sclerosis, myoclonus dystonia, chronic fatigue syndrome, and idiopathic thrombocytopenicclerosis, myoclonus dystonia, chronic fatigue syndrome, and idiopathic thrombocytopenic
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purpura.urpura.
FMT is a promising approach in the manipulation of the intestinal microbiota and has potential
applications in a variety of extra-intestinal conditions associated with intestinal dysbiosis.
Keywords: Fecal microbiota transplantation, Intestinal microbiota, Dysbiosis, Extra-intestinal disorders,
Therapy
FMT Introduction
