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Appetite has a huge impact on quality of
life—when that appetite is not there, it
takes a toll on the clients as well.
—Dr. Johannes
impact on the appetite center to increase center to stimulate appetite. It also causes
appetite, and that is ghrelin. a release of growth hormone, which
induces the production of insulin-like
I have a number of patients A New Option for growth factor 1 in the liver. The spike in
with some degree of chronic Appetite Stimulation growth hormone seen with capromorelin
becomes blunted because of negative
malnutrition in which Dr. Larson: ENTYCE® (capromorelin feedback. Rather than an uncontrolled
I am using ENTYCE® oral solution) is the first FDA- increase in growth hormone that might
approved appetite stimulant for
be deleterious, we get a subtle increase
(capromorelin oral solution). dogs. Can you tell us about its that may be advantageous—so capromo-
mechanism of action? relin increases appetite while potentially
—Dr. Burney
helping to maintain lean muscle mass.
Dr. Johannes: Regulating appetite is
not simple. There are a lot of signals Dr. Larson: Can we discuss how
coming from adipose tissue and acting on ENTYCE may be helpful in both
the hypothalamus to say “don’t eat,” but acute and chronic settings?
only the hormone ghrelin is saying “eat.”
As a ghrelin receptor agonist, capromore- Dr. Cook: Sometimes the surgical team
lin works at the hypothalamic appetite has patients recovering from traumatic
It’s not just the animals with
anorexia that can benefit.
That’s the smallest
proportion. The much bigger
populations are those with
hyporexia and dysrexia.
—Dr. Freeman
IMPORTANT SAFETY INFORMATION: ENTYCE® (capromorelin oral solution) is for use in
dogs only. Do not use in breeding, pregnant or lactating dogs. Use with caution in dogs with
hepatic dysfunction or renal insufficiency. Adverse reactions in dogs may include diarrhea,
vomiting, polydipsia, and hypersalivation. Should not be used in dogs that have a
hypersensitivity to capromorelin. Please see the full Prescribing Information for more detail.
4 clinician’s forum February 2018
