Page 2 - AITP AutoImmune Thrombocytopenia
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https://emedicine.medscape.com/article/202158‐workup



               The workup for immune thrombocytopenic purpura (ITP) starts with a complete blood cell (CBC) count.
               The hallmark of ITP is isolated thrombocytopenia; anemia and/or neutropenia may indicate other
               diseases



               On peripheral blood smear, the morphology of red blood cells (RBCs) and leukocytes is normal. The
               morphology of platelets is typically normal, with varying numbers of large platelets.



               https://www.merckmanuals.com/professional/hematology‐and‐oncology/thrombocytopenia‐and‐
               platelet‐dysfunction/immune‐thrombocytopenia‐itp



               "Immune thrombocytopenia (ITP) is a bleeding disorder caused by thrombocytopenia not associated
               with a systemic disease. Typically, it is chronic in adults, but it is usually acute and self‐limited in
               children. Spleen size is normal in the absence of another underlying condition. Diagnosis requires that
               other disorders be excluded through selective tests. Treatment includes corticosteroids, splenectomy,
               immunosuppressants, thrombopoietin receptor agonist drugs, or the spleen tyrosine kinase inhibitor
               fostamatinib. For life‐threatening bleeding, platelet transfusions, IV corticosteroids, IV anti‐D immune
               globulin, or IV immune globulin may be used individually or in combination."



               "The trigger in adults is unknown, although in some countries (eg, Japan, Italy), ITP has been associated
               with Helicobacter pylori infection, and treatment of the infection has been followed by remission of the
               ITP. "



               https://www.merckvetmanual.com/circulatory‐system/hemostatic‐disorders/platelet‐disorders


               "Primary Immune‐mediated Thrombocytopenia:

               This condition (also called idiopathic thrombocytopenia or idiopathic thrombocytopenic purpura is
               characterized by immune‐mediated destruction of either circulating platelets or, less commonly,
               marrow megakaryocytes. It has been seen in dogs, horses, and rarely cats. Clinical signs include
               petechiae of the gingivae or skin and ecchymosis, melena, or epistaxis. Platelet concentration is usually
               <50,000/μL and often <10,000/μL at the time of diagnosis. Evaluation of megakaryocytes (by bone
               marrow aspiration) helps determine whether circulating platelets or marrow megakaryocytes are
               targeted by antibody. A test for platelet factor 3 released from damaged platelets has been unreliable or
               not readily available commercially. A megakaryocyte immunofluorescence assay that detects antibodies
               on megakaryocytes has been done, but an adequate bone marrow aspiration sample must be obtained.
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